O-8: The Effect of Body Mass Index on SemenQuality and Reproductive Hormones

Background: Recent population-based studies suggest an elevated risk for subfertility among couples in which the male partner is obese and an increased likelihood of abnormal semen parameters among heavier men. Male factor infertility is associated with a higher incidence of obesity in the male partner. The aim of this review article is to study the effect of body mass index (BMI) on semen quality and reproductive hormones. Materials and Methods: This review article prepared by studdying of more than 20 articles obtained from Google, pub med sites with key words such as: Obesity; male infertility; sperm parameters; oligozoospermia; reproductive hormones; estrogen; testosteroneResults: Anette S. Aggerholm et al. (2009) reported that T and inhibin B serum concentrations were 25%-32% lower in obese men in comparison with normal-weight men, whereas the E2 concentration was 6% higher in obese men. Overweight men (BMI, 25.1-30.0 kg/m2) had a slightly lower adjusted sperm concentration and total sperm count than did men with a normal BMI (20.0- 25.0 kg/m2), but no reduction in sperm count was observed among the obese men. Floor H. Duits et al. demonstrated the group of men with a BMI>30 kg/m2 had a lower semen volume compared with the group with a BMI between 20 and 25 kg/m2. Carlsen et al. (2008 found that free androgen index and E2 increased with increasing BMI and Percentages of normal spermatozoa were reduced, although not significantly, among men with high BMI. Ahmad O. Hammoud et al. (2008) found that The incidence of oligozoospermia increased with increasing BMI: normal weight = 5.32%, overweight = 9.52%, and obese = 15.62%. The prevalence of a low15.62%. The prevalence of a lowprogressively motile sperm count was also greater with increasing BMI: normal weight = 4.52%, overweight = 8.93%, and obese = 13.28%. The incidence of erectile dysfunction did not vary across BMI categories when corrected for potential contributing factors. Jorge E et al. (2009) reported that Sperm with high DNA damage were significantly more numerous in obese men than in normal-weight men. Conclusion: The increasing prevalence of obesity calls for greater clinician awareness of its effects on fertility, better understanding of underlying mechanisms, and eventually avenues for mitigation or treatment.